Four of these cancer cell lines express mutant KRAS (Suit-2, PANC1, MDA Panc3 and HCT116) [35], whereas PaCa3, HKe3 and HKh2 lines express wild-type RAS. ATG5 depletion led to a clear reduction in CDH1 protein and mRNA expression in all cancer cell lines that express mutant KRAS, including Suit-2 (KRAS G12D), PANC1 (KRAS G12D), MDA Panc3 (KRAS G12A), and HCT116 (KRAS G13D) (Figure 1(a, b); Figure S1(a, b). Here, KRAS is linked to cancer.