In TCGA pancreatic adenocarcinoma Provisional dataset, we found that the SQSTM1 protein level was not significantly correlated with its mRNA level (Fig. S7A), which indicates a role for post-transcriptional regulation of SQSTM1 in pancreatic adenocarcinoma, consistent with the point that the SQSTM1 protein level is mainly regulated by the autophagic activity [40]. Here, SQSTM1 is linked to pancreatic adenocarcinoma.