ATG5 and neoplasm: To test the true impact of autophagy activity on tumor metastasis in vivo, a syngenic mouse model with switchable Atg3 or Atg5 in the presence or absence of oncogenic RAS is required, because we showed previously that autophagic activity dictates cellular response to oncogenic RAS-induced senescence [11], while senescent cells are able to secrete cytokines that will alter the tumor microenvironment, which is likely to have an impact on the metastatic potential in vivo [60].