This point was further strengthened by the discovery that compared to the staining in oncogenic RAS-expressing Atg5+/+ or Atg7+/+ tumor cells, RELA was accumulated in the nuclei of oncogenic RAS-expressing atg5−/- or atg7−/- tumor cells in vivo (Figure 5(b); Figure S6(a)), indicating that the NFKB pathway is activated in RAS-mutated tumors when autophagy is inhibited. Here, ATG5 is linked to neoplasm.