FASN and obesity due to melanocortin 4 receptor deficiency: In this context, Fenni et al. [38] demonstrated that the treatment with purified lycopene (10 mg/kg feed/day) for 84 days in mice submitted to a diet-induced obesity promotes decrease in the expression of SREBP-1c (a transcription factor bound to a membrane that activates lipogenic genes) and the FASN gene (which encodes an enzyme that catalyzes the synthesis of fatty acids).