In humans, several conformational diseases, or serpinopathies linked to serpin polymerization, have been identified, including emphysema serpin A1 (AAT deficiency), thrombosis serpin C1 (antithrombin) deficiency, and angioedema serpin G1 (C1 esterase inhibitor) deficiency [6]. The gene discussed is SERPINC1; the disease is pulmonary emphysema.