This local component involves the concentration of IκB, NFκB, Bax, and RIP1, and we use this to study the regulation of anti-apoptosis, apoptosis, and necroptosis in response to injections of OVs and BTZ, as well as the anti-tumor efficacy of a BTZ-OV combination therapy, at the tumor level. The gene discussed is BAX; the disease is neoplasm.