KDR and neoplasm: Liver cancer state: A recently established anti hepatocellular carcinoma agent, Sorafenib, is a multikinase inhibitor that can inhibit tumor cell proliferation and angiogenesis through the inactivation of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), c-kit receptor, and the serine-threonine kinase Raf-1.