Consistent with these findings, we observed that incubation of recombinant IFN-γ protein significantly decreased the efficacy of adenovirus infection in this study, while increased expression of SR-A and integrins on CD14+ cells was seen post IFN-γ administration, potentially causing macrophages and DCs more susceptible to adenovirus infection, which confirms previous observation that the SR-A receptor was up-regulated by IFN-γ administration on the surface of mouse macrophage cell line raw264.7 and human THP-1 monocytes and blood monocytes as well [41,42]. This evidence concerns the gene MSR1 and adenoviridae infectious disease.