Downregulation of PKCη by anti-sense oligonucleotides (ODN) enhanced vincristine- and paclitaxel-induced apoptosis in A549 lung cancer cells [43] and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in prostate cancer PC3 cells [44]. The gene discussed is TNFSF10; the disease is prostate carcinoma.