However, no phosphatidylserine externalization and caspase-8 activation was found using specific assays, thereby indicating that the cytotoxic effect of the two compounds might be ascribed to the onset of non-apoptotic cell death, as also reported for exposure of MDA-MB-231 cells to another ferrocene-containing class I HDACi (e.g., JAHA) [19] and exposure of other tumor cell model systems to the aryl-capped SAHA or depsipeptide [20]. The gene discussed is CASP8; the disease is neoplasm.