MVD evaluated on the basis of CD31 immunostaining showed a higher MVD in normal samples (24.7 ± 6.92), when compared with BPH and PC (10.19 ± 4.72 and 7.60 ± 4.41, respectively) groups, reaching statistical significance (normal versus BPH: p = 0.015; normal versus PC: p = 0.003). The gene discussed is PECAM1; the disease is pachyonychia congenita.