STAT3 and non-small cell lung carcinoma: More recently, garcinol has been shown to suppress stemness in NSCLC A549 cells through its action on Wnt/β-catenin/ Signal transducer and activator of transcription 3 (STAT3) signaling [12] and Aldehyde Dehydrogenase 1 Family Member A1 (ALDH1A1) expression [13].