CORIN and hypertensive disorder: Interestingly, PCSK6-mediated processing of corin is reduced in the presence of corin variants (T555I and Q568P) previously associated to hypertension and to heart disease in black people [39,40], as well as in the presence of corin variants (K317E, S472G, and R539C) previously identified in patients with preeclampsia and hypertension [41].