In this regard, the biological properties of the cardiac natriuretic peptides (NPs)—that is, natriuresis, diuresis, and vasorelaxation [2], implying a direct modulatory role on blood pressure homeostasis—make all components of the NP family, including the natriuretic peptide receptors (NPRA (type A natriuretic peptide receptor), NPRB (type B natriuretic peptide receptor), and NPRC (type C natriuretic peptide receptor)), and the related protease convertases (furin, corin, PCSK6), as major etiopathogenetic candidates for hypertension. The gene discussed is PCSK6; the disease is Hypertension.