Considering only septic patients (including both sepsis and septic shock), GCS, CRP, arterial blood pH, plasma lactate, the PaO2/FiO2 ratio, qSOFA and SOFA turned out to be significantly different between alive and dead patients at 30 days; OPN concentration was not different between the two groups (231.3 ng/mL in dead patients vs. 216.8 ng/mL in alive patients, p = 0.482) (Table 5). This evidence concerns the gene SPP1 and septic shock.