It has been demonstrated that AKT pathway is aberrantly activated in many human cancers and plays a central role in apoptosis inhibition through regulating p53 [39] Our data revealed that YFTL suppressed tumor proliferation and induced apoptosis via activation of the p38MAPK and JNK pathway, and down-regulating Akt pathways [40]. This evidence concerns the gene TP53 and neoplasm.