JAK2 and Familial prostate cancer: In addition, zerumbone selectively inhibited the IL-6/JAK2/STAT3 pathway and blocked the prostate cancer-associated genes- cyclin D1, IL-6, COX2 (cytochrome c oxidase), and ETS Variant 1 (ETV1); thereby inducing cytotoxicity through G0/G1 cell cycle arrest and causing apoptosis [145].