Pre-treatment with zerumbone at the tumor promotion stage in mice suppressed tumor growth and the mechanism behind its effect might be due to increased expression of xenobiotic-metabolizing enzymes (GSTP1, NQO1) and mRNA levels for manganese superoxide dismutase (MnSOD) and glutathione peroxidase-1 (GPx1). This evidence concerns the gene NQO1 and neoplasm.