In addition, zerumbone inhibited breast cancer and multiple myeloma-induced osteoclast formation through suppression of activated IkappaBalpha (IκBα) kinase (IKK), IκBα phosphorylation, and IκBα degradation, which led to the abrogation of receptor activator of nuclear factor kappa-Β ligand (RANKL)-induced NF-κB activation, which serves as a major mediator for bone resorption [64]. This evidence concerns the gene NFKB1 and breast carcinoma.