Zerumbone downregulated the expression of FLICE-like inhibitory protein (cFLIP); and in the presence of both Bax and p21, stimulated tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor (DR)4 and DR5, which intensified TRAIL-induced apoptosis in human HCT116 colon cancer cells, thus resulting in the enhanced anticancer effects of TRAIL [84]. This evidence concerns the gene TNFSF10 and colonic neoplasm.