The effect of IgE on mitochondria-regulating key meditators, including cytochrome c Oxidase Subunit 2 (COX-2), Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), and Peroxisome Proliferator-Activated Receptor γ Coactivator-1α (PGC-1α) in ASMC was determined on the pre-transcriptional and post-transcriptional level in ASMC obtained from asthma patients and controls. This evidence concerns the gene IGHE and asthma.