Our data demonstrate that ZIKV infection induces the expression of all three major PRR; retinoic-acid-inducible gene-I (RIG-I)-like receptors (RLR), toll-like receptors (TLR), and the nucleotide oligomerization domain (Nod)-like receptors (NLR) (Figure 6A). Here, RIGI is linked to Zika virus infectious disease.