In the current study, we show that in vivo activation of NK cells with poly (I:C)] in SCID mice xenografted with human T-ALL cells leads to complete cures of animals treated with the saporin-based anti-CD7 IT HB2-SAPORIN in comparison to only a 50% cure rate in animals treated with HB2-SAPORIN monotherapy. The gene discussed is CD7; the disease is acute lymphoblastic leukemia.