IRF2 and rectal cancer: The rs4648090 polymorphism has also been related to decreased risk of breast cancer among women with European ancestry [39] and to interact with other SNPs in the IFNG, IRF2, IL6, and NFKB1 genes to affect risk of colon cancer, and with IRF6 and NFKB1 genes for risk of rectal cancer [36,40].