VEGFA and essential thrombocythemia: Figure 3 shows the concentration of VEGF-A in patients with ET and in the group of healthy individuals. VEGF-A was significantly increased in patients with ET (p < 0.000001) and the median in ET patients was more than five times higher than found in the control group (Me = 137.33 pg/mL versus Me = 23.00 pg/mL).