In this regard, BMI1 is overexpressed and promotes cancer cell self-renewal in acute myeloid leukemia and several solid tumor types, such as pancreatic cancer, glioblastoma multiforme, diffuse intrinsic pontine glioma, colorectal cancer, and epithelial ovarian cancer [12,13,14,96,97,98,99,100,122]. Here, BMI1 is linked to cancer.