Furthermore, DNA- and RNA-sequencing data show that multiple cancer types, including colorectal cancer, luminal breast cancer, and ovarian cancer, frequently exhibit gene amplification or overexpression of RNF20 and/or RNF40, and/or deletion (i.e., heterozygous or homozygous deletion) and reduced expression of USP22 [15,70,91], suggesting that aberrant increases in H2BK120ub1 may also promote oncogenesis. Here, RNF20 is linked to breast cancer.