Thus, the cell viability data indicate conjugation of Dox with PDL-1 antibody significantly improved the cell killing effect of Dox at 72 h that corroborated with sustain drug release kinetics data obtained in acidic pH, as shown in Figure 2B. This observation supports the notion that PDL1-Dox will function as a potent tumor environment specific Dox delivery agent. Here, CD274 is linked to neoplasm.