However, taking also into account the different plasma kinetics of glucose and insulin in subjects with and without T2D after an oral glucose challenge [41], postprandial changes in glucose metabolism should be investigated in a close-meshed procedure, i.e., every 30–60 min for 2–3 h, to precisely assess the glycemic response in patients with T2D. This evidence concerns the gene INS and type 2 diabetes mellitus.