When subjected to an ALA-based photodynamic challenge in mitochondria, several human breast cancer lines (COH-BR1, MCF-7, MDA-MB-231) and prostate cancer lines (PC3, DU145) underwent intrinsic apoptosis that could be substantially enhanced by inhibitors of iNOS enzymatic activity (e.g., 1400W, GW274150) or by a selective NO scavenger (cPTIO) [39,40,41]. Here, NOS2 is linked to Familial prostate cancer.