NOS2 and cancer: However, until relatively recently, many other questions pertaining to NO’s anti-PDT effects have remained unanswered, e.g., (i) the major cellular source of NO in any given tumor, e.g., cancer cells vs. stromal cells; (ii) the nitric oxide synthase (NOS) isoform that produces most of this NO, and (iii) the NO-mediated signaling events that lead to PDT resistance.