FOXP3 and head and neck squamous cell carcinoma: In fact, numerous studies underlined the poor prognosis of HNSCC patients with a high FoxP3+ Treg infiltration [29,30,31] while others, such as our laboratory, rather highlighted that a high recruitment of these cells is associated with a longer overall survival and a better tumor loco-regional control [21,23,26,27,32,33].