Likewise, our multivariate analysis confirmed our univariate analysis results, demonstrating that FoxP3+ Treg infiltration in the ST compartment, tumor stage and tumor histological grade have all a strong and independent impact on RFS and OS, showing that all could be used as prognostic markers for HNSCC patients, as published in other recent studies [37,38]. Here, FOXP3 is linked to head and neck squamous cell carcinoma.