We evaluated FoxP3+ Tregs recruitment in 205 formalin-fixed paraffin-embedded (FFPE) HNSCC tumors, including HPV-negative (HPV−), HPV-positive p16-negative (HPV+ p16−) and HPV-positive p16-positive (HPV+ p16+) tumors. Here, FOXP3 is linked to head and neck squamous cell carcinoma.