In the long term, RILD patients may suffer from liver fibrosis; and expression of the key growth factors responsible for liver damage responses—such as tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), and hedgehog (Hh) signaling pathway proteins—could be significantly up-regulated [42]. This evidence concerns the gene TGFB1 and Hepatic fibrosis.