In 2012, the group of B. Kennedy demonstrated that, in the heart of Lmna−/− mice suffering of muscular dystrophy and cardiomyopathy, the increased levels of LC3-BII, Atg7, and beclin 1 proteins, generally indicating an ongoing autophagic pathway, were not followed by a decrease in p62/SQSTM1 [111], which is a marker of an active autophagic flux. This evidence concerns the gene SQSTM1 and muscular dystrophy.