LMNA and familial partial lipodystrophy, Dunnigan type: Our recent work has demonstrated that impaired autophagy due to hyperphosphorylation of pS6K1 contributes to downregulation of white adipose tissue genes in cells from FPLD2 patients, while aberrant activation of autophagy in brown preadipocytes from the neck of FPLD2 patients contributes to direct cell differentiation towards a white adipocyte phenotype (Pellegrini et al., in preparation).