Laminopathies featuring a lipodystrophy phenotype acquire partial lipodystrophy due to LMNB2 gene mutations, type 2 familial partial lipodystrophy (FPLD2), type A and B mandiboloacral dysplasia (MADA and MADB) associated with mutations in LMNA, or the prelamin A endoprotease ZMPSTE24 gene, respectively. Here, LMNB2 is linked to lipodystrophy.