GFAP and early-onset autosomal dominant Alzheimer disease: For reference, Damjanac et al. (2007) have reported that, in APPSL/PS1KI transgenic mice of Alzheimer’s disease, FJB+ cells are colocalized with hypertrophic GFAP+ astrocytes in the CA1 region at 6 to 10 months following a marked reduction of pyramidal neurons, suggesting that FJB could label activated astrocytes during a chronic neuronal degenerative process [31].