As shown in Figure 4A, the mRNA levels of Ccr7, Mmp9, c-Fos (Fos proto-oncogene, AP-1 transcription factor subunit), c-Jun (Jun), Ccl19 (C-C motif Chemokine Ligand 19) and Ccl21 were significantly reduced in tumor of CRE treated mice. This evidence concerns the gene CCL21 and neoplasm.