By secreting cytokines such as IL-6, IL-18, TNF-α, TNF-β, IL-1β, IFN-γ and IL-23, arginase 1 (ARG1) and ECM-modifying enzymes into the TME, TAMs contribute to tumor cell growth, angiogenesis, invasion and metastasis [73,76]. This evidence concerns the gene IL1B and neoplasm.