KDR and neoplasm: Sorafenib inhibit multiple receptor tyrosine kinases and Ser/Thr kinases, which includes all isoforms of Raf, all isoforms of VEGFR, and PDGFR-β, present in tumor cells and also in its surrounding vasculature and Revlimid is an immune modulatory drug that targets the immune system and other pathways including caspase-mediated apoptosis of cancer cells and prevents neovascularization [156].