The inflammatory microenvironment of the tumor recruits platelets and other blood-derived hematopoietic cells that secrete a variety of growth factors (e.g., TGF-β1), inducing the differentiation of resident fibroblasts into myofibroblasts, which in a tumor context are called cancer-associated fibroblasts (CAFs), and a response of mesenchymal stromal cells, endothelial and epithelial cells (the later via Epithelial-to-Mesenchymal transition (EMT)) and pericytes [25,120]. The gene discussed is TGFB1; the disease is neoplasm.