As an example, the presence of TNF, IL-1, IFN-γ and hypoxic conditions in the TME induces the secretion of proangiogenic and immune suppressive factors (including EGF, PDGF, fibroblast growth factor 2, FGF-2, VEGF, IL-6 and IL-10) allowing tumor proliferation [118]. The gene discussed is IL1B; the disease is neoplasm.