Choe et al. using The Cancer Genome Atlas for CRC, investigated the association between the adipokine gene family (ADIPOQ, ADIPOR1, ADIPOR2, LEP, LEPR, RETN, RETNLB, RBP4, SFRP5, NAMPT, SPP1) mRNA expression levels and the survival rate of CRC patients, observing that a high expression level of the ADIPOR1 and SPP1 genes had unfavorable outcomes on CRC patients. This evidence concerns the gene SFRP5 and colorectal carcinoma.