DMRs associated with joint disease (PsA vs. PsC probands) included the promoter and body of interleukin-22 (IL22), a cytokine produced by IL-23-driven Th17 cells, activated γδ T cells, CD8+ T cells, and monocytes [34], which was 10% hypermethylated in PsA probands. Here, IL22 is linked to arthropathy.