Although few DMRs exceeded a 10% change in methylation, it is noteworthy that many of those which did play roles in the pathogenesis of skin disease (SIGLEC14, JAM3, PCOLCE, RXRB, ELF5, IL22), joint disease (MBP, HCG26, IL22, PPP2R2D, PTPRN2) or are known to be imprinted (OSBPL5, SNORD115) (Table 2). This evidence concerns the gene ELF5 and arthropathy.