To explore whether MRS could affect the NLRP3 inflammasome signaling pathway to improve sepsis injury, we measured the expression levels of p-P65, P65, pro-caspase-1, pro-IL-1β and NLRP3/caspase-1/IL-1β by Western blotting 12 and 24 h after CLP. The gene discussed is IL1B; the disease is Sepsis.