It was reported that the levels of peak CK‐MB and IL‐6 positively correlated with the myocardial infarct size.30, 31 In addition, increased CK‐MB and IL‐6 levels represented poor clinical outcomes in STEMI patients after reperfusion therapies.34, 35 Natsukawa et al37 showed that the serum APN level on admission was significantly associated with the serum area under the curve of CK‐MB. This evidence concerns the gene IL6 and myocardial infarction.