Furthermore, CS may lead to the development of gene mutations which occurs in cell cycle–control p53 gene (TP53 in humans), which is a major cause of cancer development risk among various ethnic populations(Gibbons, Byers, & Kurie, 2014; Kytola et al., 2017; Liu et al., 2014; Wu et al., 2015). This evidence concerns the gene TP53 and cancer.