Additional recurrent mutations are observed in the genes encoding TCF3 and its negative regulator, ID3, with up to 70% of tumors bearing mutations in one or both of the genes, suggesting that TCF3/ID3 play a key role in BL lymphomagenesis.2, 4 Furthermore, Epstein‐Barr virus (EBV), a ubiquitous oncogenic virus, is associated with B‐cell lymphomas, including BL and Hodgkin lymphoma.5 The role of EBV in BL is still unclear, and it has been suggested that EBV‐positive (EBV+) and ‐negative cases might arise from different cells of origin. Here, TCF3 is linked to Burkitt lymphoma.