Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary cerebrovascular disease caused by a NOTCH3 gene mutation (Joutel et al., 1996; Goate and Morris, 1997; Rutten et al., 2014), has the clinical manifestations of recurrent ischemic stroke, progressive cognitive decline and mental disorders (Wang et al., 2011; Di Donato et al., 2017; Fang et al., 2017). The gene discussed is NOTCH3; the disease is CADASIL.