ESR1 and Stroke: Since AhR promotes apoptosis, controls ERα, and is highly expressed in brain tissue in experimental models of stroke [7, 49, 63], we hypothesize that anti-apoptotic action of DIM against OGD is mediated via inhibition of AhR/CYP1A1 and/or stimulation of ERα/CYP19A1 signaling pathways.