DAPK1 and cancer: DAPK1, a positive mediator of gamma-interferon induced programmed cell death, was reported to be fully hypo-methylated or up-regulated in several types of cancer, including fistula associated mucinous type anal adenocarcinoma (Sen et al., 2010), nasopharyngeal carcinoma (Luo et al., 2011) and gastric cancer (Zhang et al., 2006).