Accordingly, many reports have shown that upregulation of BUB1B is related to the recurrence and progression of bladder cancer (Yamamoto et al., 2007), gastric cancer (Ando et al., 2010), esophageal squamous cell carcinoma (Tanaka et al., 2008), breast cancer (Yuan et al., 2006), hepatocellular carcinoma (Liu et al., 2009) and others. This evidence concerns the gene BUB1B and hepatocellular carcinoma.