In a similar fashion the present data suggests that a consequence of vaccination with ForteMicro® alone or in combination with Renogen® appears to include down-regulation of Rho-associated Gases prior to and after infection with Asal. The Rho family of Gases is critical for successful phagocytosis in macrophages by functioning to reorganize filamentous actin, assist in NF-dB and MAPK kinase transcriptional pathways, and facilitate respiratory burst (84). This evidence concerns the gene RHO and infection.