A crucial role of endothelial NF-κB signaling has also been shown in mouse models of atherosclerosis where ablation of canonical NF-κB signaling by endothelial cell-specific deletion of NEMO or overexpression of a dominant-negative variant of IκBα protected ApoE-deficient mice from atherosclerosis induced by a Western-type diet (327). This evidence concerns the gene NFKB1 and atherosclerosis.