ST6GAL1 and AL amyloidosis: It has been known for a number of decades that changes in the level of circulatory ST6Gal-1 and the circulatory sialyl-glycan structures constructed by ST6Gal-1 are associated with a diverse array of clinical conditions including stress (6), atherosclerosis (4, 7), alcoholism (8, 9), as well as certain cancers, particularly colon and breast cancers, and multiple myeloma (10–12).