For example, lncRNA-FTH1P3 promotes melanoma cell proliferation and invasion by targeting miR-224-5p (50); lncRNA-LINC00673 contributes to HCC progression and metastasis via negative regulation of miR-205 (51); lncRNA-NEAT1 up-regulates E2F3 expression and subsequently promotes the progression of non-small cell lung cancer (52). This evidence concerns the gene E2F3 and melanoma.