NFE2L2 and myeloid sarcoma: Furthermore, increased oxidative stress is correlated with decreased Complex IV electron transport chain gene expression and Nrf2 activity in the non-lesioned gray matter of the frontal and parietal cortex, from post-mortem MS and control groups, suggesting that mitochondrial function is correlated with, if not regulated by, Nrf2 in MS (Pandit et al., 2009).