Nrf2 agonists are promising candidates in the treatment of MS, since CDDO-Im 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole, a Nrf2 activator, promoting the differentiation of the less inflammatory Th2 t cell phenotype in stimulated splenocytes of C57BL/6 mice, thereby lowering INFγ and TNFα production as well as NF-κB DNA binding (Zagorski et al., 2018). Here, NFE2L2 is linked to myeloid sarcoma.