Ramsey study did not report glial Nrf2 nuclear translocation in the SN of PD brains (Ramsey et al., 2007) and in vitro studies indicate that neuronal Nrf2 activation, even in the absence of glia, induces neuroprotection against oxidative damage triggered by parkinsonism-inducing neurotoxins (Lee et al., 2003; Cao et al., 2005; Hara et al., 2006; Jakel et al., 2007; Wruck et al., 2007; Hwang and Jeong, 2008; MacKenzie et al., 2008; Satoh et al., 2009; Niso-Santano et al., 2010). The gene discussed is NFE2L2; the disease is Parkinsonism.