NFE2L2 and Alzheimer disease: Such contrasting results may be due to differential effects on Nrf2 levels at different AD stages, perhaps indicative of an upregulation of antioxidant defenses to counteract oxidative stress in early AD stages, whilst the loss of endogenous antioxidants and Nrf2/ARE pathway activity may be more evident in latter phases of the disease (Sun et al., 2017).