PPARG and Mental deterioration: Some studies report that the long- and short-term administration of PPAR-γ agonists, such as pioglitazone and rosiglitazone, suppressed cognitive decline in aged transgenic mice (Heneka et al., 2005; Escribano et al., 2010), but to date, the effects of PPAR-γ agonists on normally aged mice have not been demonstrated.