Such a sex-specific effect of the Ar+/− animal model in cognitive behaviors has been reported in our previous publications as only male Ar+/− mice express higher level of testosterone than age- and sex-matched WT controls and showed neuroprotective effect on Alzheimer’s related cognitive impairment as well as Alzheimer’s pathology at age of 12 months (McAllister et al., 2010), while female Ar+/− mice developed early Alzheimer’s brain pathology at same age (Yue et al., 2005). The gene discussed is AR; the disease is Cognitive impairment.