TNF plays a vital role in the initiation and orchestration of inflammation and immunity (Aggarwal, 2003; Apostolaki et al., 2010; Fischer and Maier, 2015), and is potentially a key player in several neurodegenerative disorders, including Alzheimer’s disease (AD) (McAlpine and Tansey, 2008). This evidence concerns the gene TNF and Alzheimer disease.