While MCDD treatment resulted in a comparable amount of steatosis in Opn-/- mice as compared with the Opn+/+ and Opn+/- controls (Supplementary Fig. 12A), liver damage as determined by serum ALT concentrations was reduced in Opn-/- mice to a similar extent as in c-Jun∆li* mice (Fig. 7c). Here, SPP1 is linked to steatosis.