To this end and to genetically dissect the functions of c-Jun in the different liver cell compartments, mice with hepatocyte-specific knockout as well as broader c-Jun deletion in several tissues including both, hepatocytes and NPLCs, were generated and NASH was induced by the MCDD model, which recapitulates many hepatic features of NASH including fibrosis. Here, JUN is linked to metabolic dysfunction-associated steatohepatitis.