It has recently been shown that overexpression of Fra-1 and Fra-2 protects against NAFL and NASH induced by a high fat diet (HFD) by suppressing transcription of Pparγ through the action of inhibitory c-Jun∼Fra-1 or c-Jun∼Fra-2 heterodimers [12]. The gene discussed is FOSL1; the disease is metabolic dysfunction-associated steatohepatitis.