Urinary C-megalin excretion became significantly greater in quintiles with higher levels of either urinary excretion of β2MG/Cr (p < 0.001) or α1MG/Cr (p < 0.001), indicating that urinary C-megalin excretion is a relevant marker for PTECs injury and linked with the endocytic function of megalin in CKD patients. This evidence concerns the gene LRP2 and chronic kidney disease.