On the other hand, in autoimmune infection, such as, adult systemic lupus erythematosus, and rheumatoid arthritis, ADA is found at high level in the serum56 and imbalance in the ratio of cTfh2-17/cTfh1 (cTfh2-17 found at a higher frequency) has been reported45. Here, ADA is linked to rheumatoid arthritis.